Male hormonal contraception: concept proven, product in sight?
نویسندگان
چکیده
منابع مشابه
Male hormonal contraception: concept proven, product in sight?
Current male hormonal contraceptive (MHC) regimens act at various levels within the hypothalamic pituitary testicular axis, principally to induce the withdrawal of the pituitary gonadotrophins and in turn intratesticular androgen production and spermatogenesis. Azoospermia or severe oligozoospermia result from the inhibition of spermatogonial maturation and sperm release (spermiation). All regi...
متن کاملAdvances in male hormonal contraception
Contraception is a basic human right for its role on health, quality of life and wellbeing of the woman and of the society as a whole. Since the introduction of female hormonal contraception the responsibility of family planning has always been with women. Currently there are only a few contraceptive methods available for men, but recently, men have become more interested in supporting their pa...
متن کاملClinical trials in male hormonal contraception.
Research has established the principle of hormonal male contraception based on suppression of gonadotropins and spermatogenesis. All hormonal male contraceptives use testosterone, but only in East Asian men can testosterone alone suppress spermatogenesis to a level compatible with contraceptive protection. In Caucasians, additional agents are required of which progestins are favored. Clinical t...
متن کاملMale Hormonal Contraception: Where Are We Now?
Hormonal male contraception clinical trials began in the 1970s. The method is based on the use of exogenous testosterone alone or in combination with a progestin to suppress the endogenous production of testosterone and spermatogenesis. Studies using testosterone alone showed that the method was very effective with few adverse effects. Addition of a progestin increases the rate and extent of su...
متن کاملHormonal Contraception
the mechanism of transformation by RNA viruses. Benyesh-Melnick and co-workers describe the presence of DNA in purified murine leukemia-sarcoma virus preparations, suggesting that, in addition to unexpectedly complex enzymatic machinery, some tumor viruses may contain more than one type of nucleic acid. Several groups analyze differences in the membranes of transformed and normal cells. Burger,...
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ژورنال
عنوان ژورنال: Human Reproduction Update
سال: 2006
ISSN: 1460-2369,1355-4786
DOI: 10.1093/humupd/dml010